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Introduction of Penicillin v potassium tablets

2022-10-08 Hits: 25 views

Active ingredients
The main component of this product is penicillin V potassium, and its chemical name is (2S, 5R, 6R)-3,3-dimethyl -7- oxo -6-(2- phenoxyacetamido) -4- thio -1- azabicyclo [3]. 2。 0]- Heptane -2- carboxylic acid potassium salt. Molecular formula: C16H17KN2O5S Molecular weight: 388. forty-nine

Indication function
Penicillin V potassium is suitable for mild and moderate infections caused by penicillin-sensitive strains, including tonsillitis, pharyngitis, scarlet fever, erysipelas, etc. caused by streptococcus; Bronchitis, pneumonia, otitis media and sinusitis caused by pneumococcus; And skin and soft tissue infections caused by sensitive staphylococci. Penicillin V potassium can also be used as a preventive medicine for rheumatic fever recurrence and infective endocarditis, and can also be used for spirochete infection.

Indication
Tonsillitis, pharyngitis, scarlet fever, erysipelas, pneumonia, bronchitis, sinusitis, otitis media, skin and soft tissue infection, infective endocarditis, cardiovascular medicine, dermatology, infectious diseases, otolaryngology, respiratory medicine.

Method of application
Oral. Adults: Streptococcus infection is 0 every time. 118~0。 36 g (1/2 ~ 1 tablet), once every 6 ~ 8 hours for 10 days; Pneumococcal infection is 0 every time. 236~0。 72 g (1 ~ 2 tablets), once every 6 hours, for at least 2 days after the fever subsides; Staphylococcal infection, spirochete infection (Fensen angina) 0 each time. 236~0。 72 g (1 ~ 2 tablets), once every 6 ~ 8 hours; Prevent the recurrence of rheumatic fever every time 0. 26g (1 tablet), twice a day; To prevent endocarditis, take this product orally 1 hour before tooth extraction or upper respiratory surgery. 88g (8 tablets), take 0 after 6 hours. 44 g (4 tablets) (the dose for children under 27kg is halved). Children: 2 times per weight. 36~8。 [1]

Adverse effect
The common adverse reactions of oral penicillin V potassium are nausea, vomiting, epigastric discomfort, diarrhea and black hair tongue. Allergic reactions include rash, urticaria and other serum sickness-like reactions, laryngeal edema, drug fever and eosinophilia, etc. Hemolytic anemia, leukopenia, thrombocytopenia, transient increase of serum aminotransferase, neurotoxicity and nephrotoxicity are rare. Or long-term use of this product can cause double infection of penicillin-resistant, staphylococcus aureus, gram-negative bacilli or candida albicans.

Related taboos
People with positive skin test, allergic to this product and other penicillin drugs and patients with infectious mononucleosis are prohibited.

As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Penicillin V Potassium Tablets
Packaging: 10tablets/blister,10blisters/box
FEIYUE recruits agents worldwide, we can provide complete registration documents.

Pharmacological action
This product is a penicillin antibiotic. The antibacterial spectrum and action mechanism are the same as penicillin, which can kill sensitive bacteria in breeding period by inhibiting the synthesis of mucin in bacterial cell wall. This product has antibacterial activity against most gram-positive bacteria, some gram-negative bacteria (such as Haemophilus), spirochetes and actinomycetes, but most staphylococcus strains (more than 90%), including Staphylococcus aureus and coagulase-negative staphylococcus, can produce β -lactamase to inactivate this product by hydrolysis. The activity of this product against most sensitive bacteria is 2 ~ 5 times weaker than penicillin. Has no antibacterial effect on penicillinase-producing strains.

Matters need attention
(1) Before using this product, penicillin skin test must be done. The concentration of skin test solution is 1ml 500 units, and 0 is injected intradermally. 1, the positive reaction is disabled. (2) Cross-allergic reaction: People who are allergic to one penicillin may be allergic to other penicillins or penicillamine or cephalosporins. Use it with caution for those who are allergic to cephalosporins. In case of allergic reaction, you should immediately stop using this product and take corresponding measures. (3) The following situations should be used with caution: ① Patients with allergic diseases such as asthma, eczema, hay fever and urticaria; ② The elderly may need to adjust the dosage; ③ Patients with renal dysfunction should adjust the dose or dosing interval according to the plasma creatinine clearance rate. (4) Interference to diagnosis: ① During the application of this product, it can be detected when urine sugar is measured by copper sulfate method.