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Introduction of Atropine Sulfate Injection

2022-08-10 Hits: 28 views

Atropine sulfate injection, USP is a sterile solution of atropine sulfate in water for injection. Each milliliter contains 0.4 mg atropine sulfate; 9 mg of sodium chloride; Benzyl alcohol 9 mg; Water for injection qs; If necessary, the pH value can be adjusted with sulfuric acid. pH 3.0-6.5。
Atropine sulfate injection, USP can be intramuscular injection, intravenous injection or subcutaneous injection. Tropine is a white crystalline alkaloid, which can be extracted from belladonna root or synthetically produced. It is used as atropine sulfate because this compound has greater solubility.
As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Atropine Sulfate Injection
1ml: 0.5mg; 1ml: 5mg; 2ml: 1mg.
Packaging: 10 ampoules/box or 100 ampoules/box.
FEIYUE recruits agents worldwide, we can provide complete registration documents
The most important therapeutic action of atropine is the inhibition of smooth muscle and glands innervated by postganglionic cholinergic nerves. It also has central nervous system activity, which may be stimulating or depressing depending upon the dose.
Following the administration of usual clinical doses, atropine produces stimulation of the medulla and higher cerebral centers. This effect is manifested by mild central vagal excitation and moderate respiratory stimulation. Atropine sulfate also acts peripherally as a competitive antagonist of the muscarinic actions of acetycholine. It does not prevent the release of acetylcholine but antagonizes the effect of acetylcholine on the effector cells. These actions include vasodilation, drying of the mouth, an increase in the pulse rate, inhibition of contractions of the gastrointestinal tract, ureter, and bladder, and reduction of salivary, bronchial, gastric and sweat gland secretions. Following clinical and larger doses, atropine sulfate causes dilation of the pupils and paralysis of accommodation and, in narrow-angle glaucoma, can increase intraocular pressure.
Indications and usage
Atropine sulfate is administered parenterally as a pre-anesthesia drug to reduce saliva secretion and bronchial secretion. It is useful for pyloric spasm and other spasms of gastrointestinal tract. For ureteral and biliary colic, atropine sulfate and morphine may be needed. Atropine sulfate is suitable for relaxation of upper digestive tract and colon during hypotonic X-ray examination.
Tropine is used as an antidote for pilocarpine, physostigmine, isoflurane, choline ester, some kinds of aminata, and organophosphate cholinesterase inhibitor found in some pesticides and chemical warfare “nerve gas” poisoning. Large dose can relieve muscarinic symptoms and some central nervous system manifestations.
Adverse Effect
Individual tolerance varies greatly, but these systemic doses may have the following effects:
0.5mg- Slight dryness of nose and mouth, bradycardia.
1mg- drier nose and mouth, thirsty; Slow down, then the heart speeds up; Mild mydriasis.
2 mg- Very dry mouth, tachycardia, palpitation, dilated pupils and slightly blurred near vision.
5mg- Increase the above symptoms plus speech disorder, dysphagia, headache, fever, dry skin, irritability with weakness.
10mg and above- Symptoms reach extreme levels, plus ataxia, excitement, disorientation, hallucinations, delirium and coma.
65 mg- could be fatal.
A cicatricial rash may occur. Tropine may cause fever by inhibiting heat loss caused by evaporation, especially in children. Although high doses of atropine may cause worrying situations, recovery is normal.
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