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Ceftriaxone sodium for injection

2022-10-27 Hits: 20 views

Composition
Ceftriaxone sodium
Chemical name: (6R,7R)-7-[[(2- amino -4- thiazolyl) (methoxyimino) acetyl] amino ]-8- oxo -3- [[(1,2,5,6-tetrahydro -2- methyl-5,6-dioxo-2]
Molecular formula: C18H16N8Na2O7S3 3H2O
Molecular weight: 661.59
Molecular weight: 661.59
Basic traits
This product is white or white crystalline powder; Odorless.
Adapt to illness
It can be used for the prevention of lower respiratory tract infection, urinary tract and biliary tract infection caused by sensitive pathogenic bacteria, abdominal infection, pelvic infection, skin and soft tissue infection, bone and joint infection, sepsis, meningitis and other infections during operation. A single dose of this product can be used to treat simple gonorrhea.
As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Ceftriaxone sodium for injection
Packaging: 10ml tubular vial with filp-off, 1’s/box, 10’s/box, 50’s/box
FEIYUE recruits agents worldwide, we can provide complete registration documents.
Dosage
Intramuscular injection or intravenous drip.
(1) Preparation of intramuscular injection solution: add 3.6ml sterilized water for injection, sodium chloride injection, 5% glucose injection or 1% lidocaine hydrochloride into 1g bottle, and make a solution containing 250mg ceftriaxone per 1ml.
(2) Preparation of intravenous administration solution: add 9.6ml of the above-mentioned diluent (except lidocaine) into a 1g bottle to prepare a solution containing 100mg ceftriaxone per ml, and then dilute it with 5% glucose injection or sodium chloride injection for 100 ~ 250 ml and drip it intravenously.
Adults commonly use intramuscular or intravenous drip, 1 ~ 2g every 24 hours or 0.5 ~ 1g every 12 hours. The highest dose is 4g a day. The course of treatment is 7-14 days.
Intravenous drip is commonly used in children, 20 ~ 80 mg/kg per day according to body weight. Adult dosage for children over 12 years old.
The recommended dose for treating gonorrhea is a single intramuscular injection of 0.25g
Adverse effect
Adverse reactions are related to the dosage and course of treatment. The local reaction was phlebitis (1.86%), in addition to skin rash, dermatitis, pruritus, urticaria, edema, fever, bronchospasm and serum sickness (2.77%), headache or dizziness (0.27%), soft stool, diarrhea, nausea, vomiting, stomatitis, abdominal pain, colitis, jaundice, flatulence and flatulence. Abnormal laboratory examination accounts for about 19%, among which abnormal hematological examination accounts for 14%, including eosinophilia, hemorrhage, thrombocytosis or thrombocytopenia and leukopenia. Abnormal liver and kidney function were 5% and 1.4%. Other rare side effects include increased liver enzymes and decreased urine.
Taboo matters
Those allergic to cephalosporin antibiotics are prohibited.
interaction
1. When erythromycin, tetracycline, amphotericin B, vasoactive drugs (m-hydroxylamine, norepinephrine, etc.), phenytoin sodium, chlorpromazine, promethazine, vitamin B, vitamin C, etc. are added to the intravenous infusion of cephalosporins, turbidity will occur. Because there are many contraindicated drugs in this product, it should be administered separately.
2. Disulfiram-like reactions can occur in individual patients when drinking or taking alcoholic drugs during the application of this product, so drinking and taking alcoholic drugs should be avoided during the application of this product and for several days later.
Pharmacology
This product is the third generation cephalosporin antibiotic. Has strong activity against enterobacteriaceae bacteria. The MIC90 of Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, Proteus indole-positive, Brucella and Serratia ranged from 0.12 to 0.25 mg/L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa have poor sensitivity to this product. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effect on hemolytic streptococcus and pneumococcus. MIC to Staphylococcus aureus is 2 ~ 4 mg/L. Methicillin-resistant Staphylococcus and Enterococcus are resistant to this product. Most Bacteroides fragilis are resistant to this product.
Storage method
Keep in a cool and dry place (no more than 20℃), protected from light and closed.