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Application of Dexamethasone Sodium phosphate Injection

2022-06-22 Hits: 4 views

It is mainly used for allergic and autoimmune inflammatory diseases, mostly for connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc. it is also used for the comprehensive treatment of some serious infections, poisoning and malignant lymphoma.

component

The main component of this product is dexamethasone sodium phosphate.

 

character

This product is white or off white loose block.

 

indication

This product is mainly used for allergic and autoimmune inflammatory diseases. It is mainly used for connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc. it is also used for the comprehensive treatment of some serious infections, poisoning and malignant lymphoma.

 

Specifications

1ml:5mg

 

Usage and dosage

 

General dose: intravenous injection of 2-20mg each time; During intravenous infusion, it should be diluted with 5% glucose injection, which can be repeated for 2-6 hours until the condition is stable, but the continuous administration of large dose generally does not exceed 72 hours. It can also be used to alleviate brain edema caused by malignant tumors. 10mg is injected intravenously for the first time, and 4mg is injected intramuscularly every 6 hours. Generally, patients can get better after 12-24 hours, and gradually reduce after 2-4 days, and stop the drug after 5-7 days. For brain tumors that are not suitable for surgery, 50mg of the first dose can be injected intravenously, and 8mg will be given repeatedly every 2 hours. After a few days, it will be reduced to 2mg a day, and given intravenously 2-3 times. It is used for intrathecal injection of 5mg each time, once every 1-3 weeks; Intra articular injection is generally 0.8-4mg each time, depending on the size of the joint cavity.

 

Adverse reactions

 

Glucocorticoids in the application of physiological dose substitution therapy has no obvious adverse reactions. Adverse reactions mostly occur in the application of pharmacological dose, and are closely related to the course of treatment, dose, type of medication, usage and route of administration. Common adverse reactions are as follows:

 

 

 

  1. Long term use can cause the following side effects: iatrogenic Cushing’s syndrome, face and posture, weight gain, lower limb edema, purple lines, tendency to bleed, poor wound healing, acne, menstrual disorder, ischemic necrosis of the humerus or femoral head, osteoporosis and fractures (including vertebral compression fractures and pathological fractures of long bones), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea and vomiting), pancreatitis Peptic ulcer or perforation, growth inhibition in children, glaucoma, cataract, benign intracranial hypertension syndrome, impaired glucose tolerance and aggravation of diabetes.

 

  1. Patients may have mental symptoms: euphoria, excitement, delirium, restlessness, disorientation, or inhibition. Mental symptoms are caused by people who are prone to suffer from chronic consumptive diseases and have been mentally abnormal in the past.

 

  1. Infection was the main adverse reaction of adrenocortical hormone. It is mainly composed of fungi, tubercle bacillus, Staphylococcus, proteus, Pseudomonas aeruginosa and various herpes viruses.

 

  1. Glucocorticoid withdrawal syndrome. Sometimes the patient has dizziness, fainting tendency, abdominal pain or back pain, low fever, anorexia, nausea, vomiting, muscle or joint pain, headache, fatigue and weakness after drug withdrawal. After careful examination, if the hypofunction of adrenal cortex and the recurrence of the original disease can be ruled out, it can be considered as glucocorticoid dependent syndrome.

 

taboo

 

It is forbidden to use this product in patients with a history of allergy to adrenocortical hormones. In special cases, weigh the advantages and disadvantages and pay attention to the possibility of deterioration of the condition; It is generally not suitable for patients with hypertension, thromboembolism, gastric and duodenal ulcer, psychosis, electrolyte metabolism abnormality, myocardial infarction, visceral surgery, glaucoma, etc.

 

matters needing attention

 

  1. Patients with tuberculosis, acute bacterial or viral infection must be given appropriate anti infective treatment.

 

  1. After taking the medicine for a long time, it should be gradually reduced before stopping the medicine.

 

  1. Use with caution in patients with diabetes, osteoporosis, liver cirrhosis, renal dysfunction and hypothyroidism.

 

  1. Medication for pregnant and lactating women: it can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. Animal tests have teratogenic effects, so the advantages and disadvantages should be weighed. Lactating mothers should not breastfeed if they receive large doses of drugs, so as to prevent the excretion of drugs through milk, resulting in adverse reactions such as infant growth inhibition and adrenal function inhibition.

 

  1. Medication for children: if children use adrenocortical hormones, they should be very careful. The use of hormones can inhibit the growth and development of children. If it is necessary to use them for a long time, they should use short-term or medium effect preparations, avoid using long-term dexamethasone preparations, and observe the changes of intracranial pressure.

 

  1. Geriatric medication: it is easy to produce hypertension and diabetes, and it is easy to aggravate osteoporosis in elderly patients, especially women after menopause.

 

  1. Drug overdose: can cause adrenocortical hyperfunction syndrome.

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