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Amoxicillin Sodium for Injection

2022-07-15 Hits: 11 views

Component part
Ingredient: Amoxicillin sodium, its chemical name is (2S,5R,6R)-3,3- dimethyl -6-[(R)-(-)-2- amino -2-(4- hydroxyphenyl) acetamido ]-7- oxo -4- thio -1- azabicyclo [3 Molecular formula: C16H18N3NaO5S Molecular weight: 387.4

Efficacy of injection of amoxicillin sodium: Amoxicillin is suitable for patients who are seriously ill and need hospitalization or can’t take it orally in the following infections caused by sensitive bacteria (strains that don’t produce β-lactamase). 1. Upper respiratory tract infections such as otitis media, sinusitis, pharyngitis and tonsillitis caused by Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae. 2. Urogenital tract infection caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infection caused by hemolytic streptococcus, staphylococcus or Escherichia coli. 4. Lower respiratory tract infections such as acute bronchitis and pneumonia caused by Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae. 5. This product can also be used to treat typhoid fever and leptospirosis.In addition to amoxicillin sodium injection, we also have amoxicillin capsules for oral use.

Intramuscular injection or intravenous drip after dilution. 0.5 ~ 1g for adults, once every 6 ~ 8 hours. Children’s daily dose is 50 ~ 100 mg/kg, divided into 3 ~ 4 times. Patients with severe renal impairment need to adjust the dosage, among which the clearance rate of endogenous creatinine is 0.25~0.5g; every 12 hours for patients with 10 ~ 30ml/min. The creatinine clearance rate of patients less than 10ml/ min is 0.25~0.5g every 24 hours. Hemodialysis can clear this product, and amoxicillin 1g should be given after each hemodialysis.

Adverse effect
1. Gastrointestinal reactions such as nausea, vomiting, diarrhea and pseudomembranous enteritis. 2 Allergic reactions such as rash, drug fever and asthma. 3. Anemia, thrombocytopenia, eosinophilia, etc. Serum aminotransferase can be slightly increased. 5 Double infection caused by candida or drug-resistant bacteria. Occasionally, there are symptoms of central nervous system such as excitement, anxiety, insomnia, dizziness and abnormal behavior.

Penicillin allergy and penicillin skin test positive patients are prohibited.

As a generic drug supplier in China, Feiyue Pharmaceutical can provide finished drugs such as Amoxicillin Sodium for Injection
Packaging: 7ml mould vial with alum-cap, 1’s/box, 10’s/box, 50’s/box
FEIYUE recruits agents worldwide, we can provide complete registration documents.

Pharmacological action
Amoxicillin, a penicillin antibiotic, has good antibacterial activity against β -lactamase-producing strains and Helicobacter pylori of aerobic gram-negative bacteria such as Streptococcus pneumoniae and hemolytic streptococcus, Staphylococcus aureus and Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae and Neisseria gonorrhoeae. Amoxicillin plays a bactericidal role by inhibiting the synthesis of bacterial cell wall, which can make bacteria quickly become spheroids and dissolve and rupture.

Matters need attention
Class 1 penicillin drugs can occasionally cause anaphylactic shock, especially in patients with allergic history of penicillin or cephalosporin. Before taking medicine, you must ask about the history of drug allergy in detail and make penicillin skin test. If anaphylactic shock occurs, it should be rescued on the spot, and such treatment measures as keeping the airway open, taking oxygen and applying adrenaline and glucocorticoid should be taken. 2 Patients with infectious mononucleosis are prone to skin rash when using this product, so it should be avoided. 3 Patients with longer course of treatment should check their liver, kidney function and blood routine. Amoxicillin can lead to false positive urine glucose test with Benedit or Fehling reagent. 5 The following conditions should be used with caution: (1) People with a history of allergic diseases such as asthma, eczema, hay fever, urticaria, etc. (2) The dosage may need to be adjusted when the elderly and kidney function are seriously damaged. Medication for pregnant and lactating women: Animal reproduction test showed that amoxicillin, 10 times the human dose, did not damage the fertility and fetus of rats and mice. However, there is still a lack of sufficient controlled studies in humans. As animal reproduction tests can’t completely predict human reactions, pregnant women should only use this product when it is really necessary. Because a small amount of amoxicillin can be secreted in the milk, the nursing mother may cause the baby allergy after taking it. 7 Drug overdose: A prospective study involving 51 children showed that amoxicillin dose not exceed 250mg/Kg did not cause significant clinical symptoms. It is reported that a few patients suffer from renal insufficiency and oliguria due to excessive amoxicillin, but the renal impairment can be reversed after drug withdrawal.
We also have other products of Amoxicillin such as Amoxicillin sodium and flucloxacillin sodium for injection etc.